- Startseite
- Forschung
- Abschlussarbeiten
- AG Funktionelle Genetik der Neurodegeneration und neurologische Erkrankungen
- AG Mechanistische Zellbiologie
- AG Neuromuskuläre und skelettale Erkrankungen
- AG Seltene und erbliche Nierenerkrankungen
- AG Skeletterkrankungen und genetische Syndrome
- AG Struktur und Stabilität des (Epi)Genoms
- Publikationen
- Habilitationen
- Doktorarbeiten
- Abschlussarbeiten
Abschlussarbeiten
Bachelor
Janek Bieler: Optogenetic inhibition of the AIS located mitochondrial cluster in hiPSC-derived neurons
Angela Esser: Investigating the Localization of RALA in Different Cell Cycle Phases using Subcellular Fractionation
Master
Elham Raezaei: Investigating the role of CDK1 phosphorylation of DRP1 recruitment at mitochondria during mitosis
Tamara Wied: Investigating the Interplay Between Tubulin Tyrosine Ligase-Like Enzymes and the Microtubule-Associated Protein TAU in Human Cell Models
Bachelor
Yara Zemke: Identifying the interaction of the motor protein Myosin XIX and the mitochondrial adaptor protein Miro through in vitro studies and cellular assays
Thilo Löhr: Production of functional L2HGDH for treating L-2-hydroxyglutaric aciduria using Adeno-associated virus
Felicia Tröger: Modelling a neuromuscular disease caused by ERC2 knockout using genome editing in human induced pluripotent stem cells
Master
Sebastian Voss: Uncovering the mechanisms regulating mitochondrial dynamics during cell division
Daniel Adam: Study of Tau axon-to-soma diffusion in human iPSC-derived neurons in paradigms of mitochondrial and AIS impairment
Master
Lena Kluge: Virus-based knockdown of TAU isoforms in iPSC-derived neurons as a gene therapy approach for Alzheimer´s disease and related dementia syndromes
Felix Langerscheidt: Lentiviral production and expression of polymerase-γ, associated proteins and regulators of mitochondrial biogenesis
Timo Lange: Cell-type specific atlas of methylation - correlating scEMseq references for methylation deconvolution and expression profiles from scRNA in human tissue
Master
Jennifer Oly: Treatment approaches for the neurogenetic Alpers syndrome and other POLG-related mitochondriopathies using two neuronal cell models and patient fibroblasts
Lisa Wolff: Study of the SMA protective modifiers PLS3 and CHP1 in neurodegenerative disorders
Bachelor
Magdalena Krubner: Role of miRNAs in Spinal Muscular Atrophy
Master
Michael Bell: Exploring mechanisms of axonal Tau sorting in human SH-SY5Y-derived and primary mouse neurons
Tamas Schmidt: Characterization of STIM1 as a novel PLS3 binding partner in spinal muscular atrophy
Bachelor
Michelle Scharte: Generation of spinal muscular atrophies modyfiers knockout cell lines using CRISPR/Cas9
Master
Lea Middelmann: A new high throughput technique for the molecular diagnosis of polycystic kidney disease patients
Bachelor
Charlotte Marie Johanna Dresen: Functional Analysis of Vesicle Trafficking in Spinal Muscular Atrophy
Bachelor
Johanna Brecht: Characterization of microRNA processing enzyme, Drosha in Spinal Muscular Atrophy
Master
Björn Reusch: MAGED2 associated polyhydramnions and transient Bartter-like syndrome
Maximilian Thelen: Characterization of ATP Synthesis in Spinal Muscular Atrophy
Master
Wiebke Rehorst: Characterization of Intercellular Communication Mechanisms at the Neusomuscular Junction in Spinal Muscular Atrophy
Nadine Rosin: Novel Insights into Molecular Mechanisms Underlying Syndromic Microcephaly
Master
Inês do Carmo Gil Gonçalves: The role of SMN protein in miRNA biogenesis
Nasim Biglari: Identification of interacting partners of a modifier of spinal muscular atrophy
Bachelor
Kristina Vogtmann: Promoter analysis of Akt1 and mTOR in spinal muscular atrophy
Master
Janine Milbradt: Cytoskeleton modifiers in bone development
Eva Janzen: Identification of Binding Partners of Plastin 3, a Modifier of Spinal Muscular Atrophy
Master
Mario Paterno: In vitro und in vivo Charakterisierung des Histon-Deacetylase-Inhibitors JNJ-26481585 als potenzielles Therapeutikum für die autosomal rezessive proximale spinale Muskelatrophie (SMA)
Bachelor
Stefanie Rösler: Molecular basis of inheritable cone-rod dystrophy associated with myopia magna; Identification and characterization of a novel gene defect
Master
Lilian Martinez: Molecular analysis of the OCLN gene in patients with spinal muscular atrophy and brain atrophy
Rainer Akkermann: Peroxisome proliferator-activated receptor δ expression in myeloid cells mediates sex differences in recovery from paralysis in experimental autoimmune encephalomyelitis
Master
Immanuel Weber: Search for potential modifiers in Spinal Muscular Atrophy patients
Guido Neidhardt: The epigenetic regulation of glutamate transporters in malignant glioma
Bachelor
Henrike Kristen: Der Einfluss des HDAC-Inhibitors M344 auf das Spleißen von SMN2 in Smn-/-, Smn+/+ und Sfrs10- defizienten murinen embryonalen Fibroblasten
Master
Agata Nasilowska: The molecular role of histone deacetylase (HDAC) isozymes in glioma progression and therapy
Diplom
Stephanie Friedrichs: Generierung von murinen induziert pluripotenten Stammzellen und deren Differenzierung in Motoneurone
Katharina Keupp: Genetische und funktionelle Charakterisierung autosomal rezessiver Taubheitsgene