Master's
Thilo Löhr: Characterization of iPSC-derived glutamatergic wild-type and TAU KO neurons using two differentiation protocols
Laura Köhler: Microtubule dynamics in models of tauopathy—preparatory experiments for AAV-based gene therapy
Bachelor's Degree
Deborah Liu: Biochemical characterization of the role of RALBP1 in the phosphorylation of DRP1 by CDK1 during mitosis
Janek Bieler: Optogenetic inhibition of the AIS-localized mitochondrial cluster in hiPSC-derived neurons
Angela Esser: Investigating the Localization of RALA in Different Cell Cycle Phases Using Subcellular Fractionation
Master
Elham Raezaei: Investigating the role of CDK1-mediated phosphorylation of DRP1 in its recruitment to mitochondria during mitosis
Tamara Wied: Investigating the Interplay Between Tubulin Tyrosine Ligase-Like Enzymes and the Microtubule-Associated Protein TAU in Human Cell Models
Bachelor's Degree
Yara Zemke: Identifying the interaction between the motor protein Myosin XIX and the mitochondrial adaptor protein Miro through in vitro studies and cellular assays
Thilo Löhr: Production of functional L2HGDH for treating L-2-hydroxyglutaric aciduria using adeno-associated virus
Felicia Tröger: Modeling a neuromuscular disease caused by ERC2 knockout using genome editing in human induced pluripotent stem cells
Master
Sebastian Voss: Uncovering the mechanisms regulating mitochondrial dynamics during cell division
Daniel Adam: Study of tau diffusion from axon to soma in human iPSC-derived neurons in models of mitochondrial and AIS impairment
Master's
Lena Kluge: Virus-based knockdown of TAU isoforms in iPSC-derived neurons as a gene therapy approach for Alzheimer’s disease and related dementia syndromes
Felix Langerscheidt: Lentiviral production and expression of polymerase-γ, associated proteins, and regulators of mitochondrial biogenesis
Timo Lange: Cell-Type-Specific Atlas of Methylation—Correlating scEMseq References for Methylation Deconvolution and Expression Profiles from scRNA in Human Tissue
Master's
Jennifer Oly: Treatment approaches for the neurogenetic Alpers syndrome and other POLG-related mitochondriopathies using two neuronal cell models and patient fibroblasts
Lisa Wolff: Study of the SMA protective modifiers PLS3 and CHP1 in neurodegenerative disorders
Bachelor's Degree
Magdalena Krubner: The Role of miRNAs in Spinal Muscular Atrophy
Master
Michael Bell: Exploring mechanisms of axonal Tau sorting in human SH-SY5Y-derived and primary mouse neurons
Tamas Schmidt: Characterization of STIM1 as a novel PLS3 binding partner in spinal muscular atrophy
Bachelor's Degree
Michelle Scharte: Generation of spinal muscular atrophy modifier knockout cell lines using CRISPR/Cas9
Master
Lea Middelmann: A New High-Throughput Technique for the Molecular Diagnosis of Patients with Polycystic Kidney Disease
Bachelor's Degree
Charlotte Marie Johanna Dresen: Functional Analysis of Vesicle Trafficking in Spinal Muscular Atrophy
Bachelor's Degree
Johanna Brecht: Characterization of the microRNA processing enzyme Drosha in Spinal Muscular Atrophy
Master's
Björn Reusch: MAGED2-associated polyhydramnios and transient Bartter-like syndrome
Maximilian Thelen: Characterization of ATP Synthesis in Spinal Muscular Atrophy
Master's
Wiebke Rehorst: Characterization of Intercellular Communication Mechanisms at the Neuromuscular Junction in Spinal Muscular Atrophy
Nadine Rosin: Novel Insights into the Molecular Mechanisms Underlying Syndromic Microcephaly
Master's
Inês do Carmo Gil Gonçalves: The role of the SMN protein in miRNA biogenesis
Nasim Biglari: Identification of interacting partners of a modifier of spinal muscular atrophy
Bachelor's Degree
Kristina Vogtmann: Promoter Analysis of Akt1 and mTOR in Spinal Muscular Atrophy
Master
Janine Milbradt: Cytoskeletal Modifiers in Bone Development
Eva Janzen: Identification of Binding Partners of Plastin 3, a Modifier of Spinal Muscular Atrophy
Master's
Mario Paterno: In vitro and in vivo characterization of the histone deacetylase inhibitor JNJ-26481585 as a potential therapeutic agent for autosomal recessive proximal spinal muscular atrophy (SMA)
Bachelor's Degree
Stefanie Rösler: Molecular Basis of Inheritable Cone-Rod Dystrophy Associated with Myopia Magna; Identification and Characterization of a Novel Gene Defect
Master
Lilian Martinez: Molecular analysis of the OCLN gene in patients with spinal muscular atrophy and brain atrophy
Rainer Akkermann: Peroxisome proliferator-activated receptor δ expression in myeloid cells mediates sex differences in recovery from paralysis in experimental autoimmune encephalomyelitis
Master's
Immanuel Weber: Search for Potential Modifiers in Patients with Spinal Muscular Atrophy
Guido Neidhardt: The epigenetic regulation of glutamate transporters in malignant glioma
Bachelor's
Henrike Kristen: The Effect of the HDAC Inhibitor M344 on SMN2 Splicing in Smn-/-, Smn+/+, and Sfrs10- Deficient Murine Embryonic Fibroblasts
Master
Agata Nasilowska: The molecular role of histone deacetylase (HDAC) isozymes in glioma progression and therapy
Diploma
Stephanie Friedrichs: Generation of murine induced pluripotent stem cells and their differentiation into motor neurons
Katharina Keupp: Genetic and functional characterization of autosomal recessive deafness genes